Comparative Effect of Indole-3-carbinol and Its Metabolite 3, 3’- Iindolylmethane on Glycemic Control; a Dose Response Study

The World is facing diabetic explosion and the cause may be both nature and nurture. According to the World Health Organization (WHO), diabetes mellitus affects approximately 171 million people worldwide and the number is expected to reach to 366 million in 2030 (Amos et al., 2010). Evidence is accumulating that the fundamental defect of type 2 diabetes mellitus (T2DM) is primarily associated with insulin resistance. The consistent data throughout the world also shows that obesity, associated insulin resistance, and T2DM have dramatically increased in locations where lifestyles have recently been westernized (Martin et al., 1992). Even though there were loads of drugs that can be used as treatment modalities for T2DM they can cause undesirable side effects or contraindications consequently there was a necessity to develop the plant based drugs to overcome myriad of problems. In this study the genetically modified mice (C57BL/6J) that mimic human abnormalities of T2DM were used for preclinical studies.